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To the 110-th anniversary of renin finding. Fight of Titans: angiotensin converting enzyme inhibitors and sartans

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Author(s): L.N. Malay | A.N. Miroshnichenko | B.V. Sharykin | V.V. Konurovsky

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 5;
Issue: 4;
Start page: 85;
Date: 2009;
Original page

Keywords: angiotensin converting enzyme inhibitors | angiotensin II receptor blockers | cardiovascular diseases.

ABSTRACT
Angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB) slow down progression of cardiovascular diseases and reduce risk of mortality and life threatening complications. What it is better to prescribe for patient in a concrete clinical case – ACE inhibitors or ARB? Authors compare these drug classes (mechanism of action, indications, evidense base of clinical trails, treatment costs and safety). The place of ACE inhibitors and ARB in modern therapy of cardiovascular diseases is defined. Results of the recent trails (ONTARGET, TRANCEND, PRoFESS, I-PRESERVE) are discussed.
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