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13. Simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in tablet dosage form

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Author(s): R. Arun | A. Anton Smith

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 02;
Issue: 03;
Start page: 201;
Date: 2011;
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Keywords: Artemether | Lumefantrine | Antimalarial | Simultaneous determination | Method development | Method validation | RP-HPLC

ABSTRACT
This paper describes the development and validation of a simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in fixed-dose combination tablets. The method showed to be linear (r2 > 0.999), precise (RSD < 0.43%), accurate (recovery of 99.81% for artemether and 99.54% for lumefantrine), speciļ¬c and robust. Three batches of artemether and lumefantrine tablets were assayed by the validated method. The artemether contents in the tablets varied from 99.30 to 99.33%, while lumefantrine contents were 99.65 to 99.66%.

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