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18F-fluoro-2-deoxyglucose uptake on PET CT and glucose transporter 1 expression in colorectal adenocarcinoma

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Author(s): Ran Hong | Sung-Chul Lim

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 18;
Issue: 2;
Start page: 168;
Date: 2012;
Original page

Keywords: 18F-fluoro-2-deoxyglucose | Glucose transporter 1 | Colorectal cancer

ABSTRACT
AIM: To evaluate the correlation between the level of 18F-fluoro-2-deoxyglucose (18F-FDG) uptake and glucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA). METHODS: Forty four patients with resected CRA and preoperative 18F-FDG positron emission tomography - computed tomography data were investigated in this study. Comparison of maximum standardized uptake value (SUVmax) of the lesion was made with GLUT1 expression by immunohistochemistry and various clinicopathologic factors including tumor volume, invasion depth, gross finding, and lymph node metastasis. RESULTS: SUVmax was 14.45 ± 7.0 in negative GLUT1 expression cases, 15.51 ± 5.7 in weak GLUT1 expression cases, and 16.52 ± 6.8 in strong GLUT1 expression cases, and there was no correlation between between GLUT1 expression and SUVmax. SUVmax was significantly correlated with tumor volume (P < 0.001). However, there was no significant differences in SUVmax and GLUT1 expression among other clinicopathologic factors. CONCLUSION: GLUT1 expression does not correlates significantly with 18F-FDG uptake in CRA. 18F-FDG uptake was increased with tumor volume, which is statistically significant.
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