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1. Antidiabetic efficacy of leaf extracts of Asteracantha longifolia (Linn.) Nees. on alloxan induced diabetics in male albino wistar rats

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Author(s): M. Muthulingam

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 02;
Start page: 28;
Date: 2010;
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Keywords: Asteracantha longifolia | Alloxan | Antioxidant enzymes | Glucose | Pancreas

ABSTRACT
The present study was undertaken to investigate the effect of aqueous extract of Asteracantha longifolia on alloxan induced diabetics in male albino Wistar rats. Alloxan induced diabetic rats were treated with aqueous extract of Asteracantha longifolia at the doses of 100, 200 and 400 mg/kg, p.o. and its influence on glucose level, insulin, hemoglobin, glycosylated hemoglobin, alanine transaminase, aspartate transaminase, serum total cholesterol, levels of pancreas enzymatic and non-enzymatic antioxidant enzymes (superoxide dismutase, catalase and reduced glutathione) were observed. Histological observation of pancreas also studied. Oral administration of aqueous extract of Asteracantha longifolia at the dose of 100, 200 and 400 mg/kg, p.o. to alloxan treated rats showed significantly decrease in plasma glucose, glycosylated hemoglobin, alanine transaminase, aspartate transaminase, serum total cholesterol, where as plasma insulin, hemoglobin, levels of pancreas enzymatic and non-enzymatic antioxidant enzymes (superoxide dismutase, catalase and reduced glutathione) were significantly increased. Histopathological observation of pancreas reverses the trends towards normalcy. Hence, it can be concluded that Asteracantha longifolia leaf extracts may be prove to be effective in the treatment of diabetes mellitus owing to its ability to increase insulin secretion and enhance the antioxidant activity.
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