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1. Synthesis and evaluation of anticonvulsant and antimicrobial activities of some Mannich bases of substituted aminophenol and acetophenone

Author(s): P. Muthumani | Neckmohammed | R. Meera | S.Venkataraman | N. Chidambaranathan | P. Devi | C.A. Suresh Kumar

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 03;
Start page: 78;
Date: 2010;
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Keywords: Mannich reaction | Aminophenol derivatives | Acetophenone derivatives | Anticonvulsant and antimicrobial activities

In this study, some Mannich bases of substituted aminophenol and acetophenone has been synthesized and their anticonvulsant and antimicrobial activities were evaluated. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant activity shows that there is a significant reduction of duration of extension phase with compounds IE, IF, IID, IIIA, IVC and VB, at P

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