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1. In vitro and in vivo evaluation of ethyl cellulose based floating microspheres of cefpodoxime proxetil

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Author(s): Amol V. Pande | Pravin D. Vaidya | Aseem Arora | Madhura V. Dhoka

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 04;
Start page: 122;
Date: 2010;
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Keywords: Cefpodoxime proxetil | Floating microspheres | Solvent evaporation technique | Ethyl cellulose | HPMC K100M

ABSTRACT
In the present study, an attempt was made to develop GRDDS for cefpodoxime proxetil using Ethyl cellulose and HPMC as a release retarded material by solvent evaporation technique. Four different batches of microspheres were prepared by varying the concentration of ethyl cellulose from 1 to 4 g. The microspheres were characterized for drug content, percentage yield, particle size analysis and surface morphology. It was observed the increase in concentration of ethyl cellulose increases the entrapment efficiency and mean particle size of the microspheres. The effect of polymer concentration on the in vitrorelease of cefpodoxime proxetil from the microspheres was also studied. It can be seen that by increasing the polymer concentration, decreases the rate of drug release from the microspheres dramatically. The best microsphere formulation was selected based on the in vitro release profile and subjected for further pharmacokinetic studies. An in vivo studies revealed that the relative bioavailability of the drug increased by more than 1.5 times by formulating it into microspheres.

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