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2D QSAR of arylpiperazines as 5-HT1A receptor agonists

Author(s): Joshi Urmila | Tikhele Sonali | Shah F

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 69;
Issue: 6;
Start page: 800;
Date: 2007;
Original page

Keywords: 5-HT1A receptor | arylpiperazines | agonists | QSAR

Of the various structurally diverse compounds known to bind 5-HT 1A receptor sites, arylpiperazine derivatives represent one of the most important classes. This article deals with the development of a QSAR equation relating the ligand binding activity of various literature reported arylpiperazines acting as agonists at the 5-HT 1A receptor to their 2D descriptors. Significant equation was generated using MOE 2004.03 and validated subsequently using leave one out and test set prediction methods. The equation revealed the importance of combination of electronic and lipophilic parameters in explaining the observed variance.
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