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3. A comparative study of outcome of labour induction with vaginal misoprostol versus intravenous oxytocin in premature rupture of membranes beyond 36 weeks of gestation

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Author(s): Vidyadhar B. Bangal | Purushottam A. Giri | Bhaumik G. Shah

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 02;
Issue: 04;
Start page: 233;
Date: 2011;
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Keywords: Bishops score | Induction of labor | Misoprostol | Oxytocin | Premature rupture of membranes

ABSTRACT
Induction of labour is indicated, when it is agreed that the fetus or mother will benefit with a higher probability of a healthy outcome, than if birth is delayed. Oxytocin is being used for decades for the purpose of labor induction in premature rupture of membranes (PROM). misoprostol (PgE1), a newer prostaglandin has shown promising results for the same purpose. The efficacy and safety of vaginal misoprostol and intravenous oxytocin for labor induction, in premature rupture of membranes beyond 36 weeks of gestation was evaluated and compared. A prospective randomized study of two hundred women (100 each from vaginal misoprostol group and intravenous oxytocin group) with premature rupture of the membranes beyond 36 weeks' of gestation, was carried out for two years at Pravara Rural Hospital, Loni. Results were analysed using Statistical Package of Social Sciences (SPSS) v13.0. Induction to delivery interval was significantly longer (p

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