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3. Design and evaluation of sustained release microcapsules containing diclofenac sodium

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Author(s): B. AppaRao | M.R. Shivalingam | Y.V. Kishore Reddy | N. Sunitha | T. Jyothibasu | T. Shyam

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 03;
Start page: 90;
Date: 2010;
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Keywords: Diclofenac sodium | Non steroidal anti-inflammatory drugs | Microencapsulation | Ethyl cellulose | Sustained drug release | Release kinetic studies

ABSTRACT
Prolonged-release microcapsules of diclofenac sodium (DS) were prepared by employing ethyl cellulose as a polymer in various ratios of 1:1, 2:3 & 2:1, by emulsion solvent evaporation technique. Scanning electron microscope photographs of samples revealed that all prepared microcapsules were almost spherical in shape and have a slightly smooth surface. The encapsulation efficiency was found to be in the range of 66.17-72.99%. The in vitro release profile of diclofenac indicates that all the batches of microcapsules showed controlled and prolonged drug release over an extended period of 10 h. The release kinetics study reveals that the drug follows first order kinetics and the mechanism of drug release was diffusion controlled type. From the in vitro drug release profiles, it was also observed that the drug release from microcapsules was decreased with an increase in coating material in the microcapsules. Infrared spectroscopic studies indicate that there is no chemical interaction between drug and carrier, and the drug is stable in the formulated microcapsule product.
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