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4. Cisplatin and carboplatin induced changes in oxidative enzyme activity levels in albino rat’s liver

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Author(s): Y.V. Kishore Reddy | P. Sreenivasula Reddy | M.R. Shivalingam | B. Appa Rao | K. Sindhura | G. Vasavya Sindhu | M. Vijay Bhaskar Reddy

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 03;
Start page: 94;
Date: 2010;
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Keywords: Cisplatin | Carboplatin | SDH | LDH | G-6-PDH | Liver | Albino rats

ABSTRACT
The present study aimed to investigate the possible interference of cisplatin or carboplatin on oxidative enzymes in liver of albino rats. Rats were divided into three groups each consisting of eight animals. Group 1 (Control) received 0.9% of normal saline. Group 2 (Treatment) received cisplatin of 3 mg/kg body weight and Group 3 (Treatment) received carboplatin of 10 mg/kg body weight. Injections were given intra-peritoneally to rats on 1st, 3rd and 5th day of experimentation. On 45th day of experiment, animals were sacrificed by cervical dislocation. Succinate dehydrogenases (SDH), Lactate dehydrogenase (LDH), Glucose-6-phosphate dehydrogenase (G-6-PDH) activities in the cytosol fraction were assayed in liver of albino rats. Cisplatin or carboplatin treatment caused significant changes in activity levels of SDH, LDH & G-6-PDH in liver of experimental rats, when compared to control rats. From the study it may be concluded that, hepatic tissue is meeting its energy requirements through alternative pathways. In other words this can be viewed as functional or physiological adaptation of the liver in treated rats, may be due to stress caused by platinum-based anticancer drugs.
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