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4. Effect of intraperitoneal administration of Ghrelin hormone in testis of immature and mature male albino rats to study histoarchitecture

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Author(s): S. Antonyselvi | D. Raja Kumar | Shanthi Palanivelu | P. Anand

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 02;
Start page: 85;
Date: 2012;
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Keywords: Ghrelin | Male albino rats | Spermatogenesis | Testis

ABSTRACT
The aim of our present study is to assess the histophysiological changes in the testis of immature and mature wistar strain male albino rats in response to the intraperitoneal injection of Ghrelin hormone. Eighteen immature male albino rats (45-55 days old) and eighteen mature male albino rats (3-4 months old) were randomly divided into control and experimental groups (two doses as lower dose - 10µg/kg and optimum dose - 20µg/kg of body weight of Ghrelin). The experimental animals were injected with Ghrelin for 15 days .On 16th day the animals were sacrificed. The body weight and weight of testes were measured .The testes were fixed in10% buffered formalin and stained with haematoxylin and eosin. The histo-architecture of testis was studied. Results: Administration of Ghrelin significantly affected the terminal stages of spermatogenesis in a dose dependent manner. Well defined changes like interstitial edema, reduction in number of Sertoli cells were seen in the testis of animals of optimum dose when compared with other two groups. In immature and mature group there was significant increase in body weight of treated animals. In mature group significant increase in testis weight of optimum dose was seen when compared with other two groups Conclusion: From the present study it may be concluded that Ghrelin produced degenerative changes in the testis of albino rats and thus it may have a negative influence on reproductive function and fertility.
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