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4. Hepatoprotective activity of Kigelia africana and Anogeissus accuminata against paracetamol induced hepatotoxicity in rats

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Author(s): K.Hemamalini | B.Preethi | Anurag Bhargav | Uma Vasireddy

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 03;
Start page: 152;
Date: 2012;
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Keywords: Kigelia Africana | Anogeissus accuminata | Paracetamol | Hepatoprotective | Hepatotoxicity

ABSTRACT
The present study was conducted to evaluate the hepatoprotective activity of methanolic extracts of Kigelia africana and Anogeissus accuminata against paracetamol induced liver damage in rats. The methanolic extracts of Kigelia africana (200 mg/kg) and Anogeissus accuminata (300 mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (25 mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 1% Tween-80 solution. The plant extract was effective in protecting the liver against the injury induced by paracetamol in rats. This was evident from significant reduction in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and Total bilirubin (TB). It was concluded from the result that the methanolic extract of Kigelia Africana and Anogeissus accuminata possesses hepatoprotective activity against paracetamol induced hepatotoxicity in rats.
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