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5-Fluorouracil-associated bradycardia: case report

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Author(s): Muhammet Ali KAPLAN | Timuçin ÇİL | Abdurrahman IŞIKDOĞAN

Journal: Turkish Journal of Oncology
ISSN 1300-7467

Volume: 25;
Issue: 3;
Start page: 115;
Date: 2010;
Original page

Keywords: Bradycardia | chemotherapy | 5-fluorouracil.

ABSTRACT
5-Fluorouracil (5-FU) is a synthetic, fluorinated pyrimidine antagonist, which is a cytostatic agent. Cardiotoxicity is a rare but important side effect of 5-FU. The cardiotoxicity incidence of 5-FU is increasing in conjunction with its frequent use in chemotherapy protocols. Ischemic symptoms and signs related to 5-FU are observed during the late phase of the drug administration. Monitoring should be done in all patients having coronary artery disease. There are many treatment options and prophylactic modalities for 5-FU cardiotoxicity. Herein, we present the rare case of a patient with cardiotoxicity during short 5-FU infusion.
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