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The р53 expression in cells of marginal zone of duodenal ulcers during acute bleeding

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Author(s): Sulayeva O.N. | Barinov E.F. | Ignatyeva L.N. | Baranova K.V.

Journal: Морфологія
ISSN 1997-9665

Volume: 3;
Issue: 3;
Start page: 116;
Date: 2009;
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Keywords: duodenum | ulcer bleeding | apoptosis

ABSTRACT
The aim of the work was to estimate the intensity and tissue distribution of proapoptogen p53 expression in duodenal mucosa in patients with acute bleeding caused by peptic ulcers. In 31 patients (1st group) the healing of ulcer was detected after effective endoscopic hemostasis and in 15 patients rebleeding took place (2nd group). Performed immunocytochemical investigation allow to determine that acute ulcer bleeding was associated with activation of marginal zone cells apoptosis which was maximal in covering epithelium, vascular endothelium and regions infiltrated by lymphocytes. In patients with rebleeding the higher values of р53 expression were detected in crypts epithelium and in endothelium of dilatating vessels accompanied with intensive edema and lymphocytes infiltration of lamina propria and muscularis mucosae with perifocal activation of cells death. Additionally to apoptosis in 2nd group duodenum the necrosis of cells and epithelium desquamation were found, reflecting the tissue disintegration of duodenal mucosa.
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