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5. Evaluation of the hypoglycemic effect of aqueous extract of Phyllanthus amarus in alloxan-induced diabetic albino rats

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Author(s): Herbert O.C. Mbagwu | Clement Jackson | Idongesit Jackson | Godwin Ekpe | Udeme Eyaekop | Grace Essien

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 02;
Issue: 03;
Start page: 158;
Date: 2011;
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Keywords: Hypoglycemic | Aqueous extract | Phyllanthus amarus Schum | Alloxan- induced diabetes

ABSTRACT
The hypoglycemic potential of aqueous extract of Phyllanthus amarus Schum was investigated in alloxan-induced diabetic albino rats. The extract at a dose of 260 mg/kg produced a significant (P< 0.05) reduction in blood glucose level by 112% at 24 h of oral administration. At 390 mg/kg, significant reduction (P< 0.05) in blood glucose levels of 102% (6 h) and 82% (24 h) were observed. A significant reduction (P
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