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5. Phytochemical, anti-bacterial, antidiarrhoeal and analgesic activity of Brownlowia tersa (Linn.)

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Author(s): Md.Samiul Huq Atanu | Imran Ashab | Md.Shariful Islam Howlader | Md.Raihan Sarkar | K.M.Muhsinin Mahbub | Shah Marzia Mahjabin Lina

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 03;
Start page: 157;
Date: 2012;
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Keywords: Brownlowia tersa | Antibacterial | Antidiarrheal | Analgesic | Loperamide | Acetic acid

ABSTRACT
Brownlowia tersa (Linn.) (Family: Tiliaceae) is a medicinal plant with various pharmacological activity. The purpose of the present study was to determine phytochemical groups present and investigate the in-vitro antibacterial activity and antidiarrheal and analgesic activity of ethanol extract of leaf by using Swiss-Albin mice. Phytochemical analysis gave positive results for carbohydrates, glycosides, saponins, tannins, flavonoids and alkaloids. Antibacterial activity was evaluated by disc-diffusion method and the extract exhibited antimicrobial activities with zones of inhibition ranging from 8 to 13mm against gram-positive bacteria but exhibit no susceptibility against gram-negative bacteria. The anti-diarrheal activity of the alcohol extract of the leaves of Brownlowia tersa was investigated by castor oil induced diarrhea in mice. The parameters of this study were mean weight of stool and latent period of defecation of mice. The percentage protection in extract treated animals showing diarrhea was compared with castor oil treated and Loperamide treated animals. The results revealed that the alcohol extracts significantly reduced diarrhea in mice and revealed a dose dependent relationship. Acetic acid induced writhing in mice was used as the process to evaluate the analgesic activity. The inhibition of writhing was calculated in respective to control (vehicle). The test samples were administered at two doses of 250mg/kg and 500mg/kg body weight of experimental animals where diclofenac sodium at a dose of 25mg/kg body weight was used as standard drug in this study. The extract exerts dose dependent relationship in analgesic activity.
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