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6. Effect of ethanolic fruit extract of Xylopia aethiopica on reproductive function of male rats

Author(s): E. Woode | A. Alhassan | Chrissie S. Abaidoo

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 02;
Issue: 03;
Start page: 161;
Date: 2011;
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Keywords: Androgenic | Reproduction | Spermatogenesis | Xylopia aethiopica

This study evaluated the effect of 70% alcoholic extract of Xylopia aethiopica on reproductive function of adult male rats. Ethanolic fruits extract of X. aethiopica was administered orally to groups of male Sprague Dawley rats at the doses of 30, 100 and 300 mg/kg for 60 days. The reproductive organ weights, change on animal body weight, caudal epididymal sperm count, motility and viability, histology of testes and androgenic hormones levels were evaluated. Increase in body weight as well as weight of testis and epididymis and a significant increase in caudal sperm count was noticed. Transverse sections of testis exhibited spermatogenesis. The extract treatment also showed significant increase in serum testosterone and luteinizing hormone levels. The studies clearly reveal androgenic activity of the extract and its effects on hypothalamic pituitary gonadal axis.
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