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6. Formulation and invitro characterization of domperidone loaded solid lipid nanoparticles

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Author(s): Lakshmi Sirisha Kotikalapudi | Laxminarayana Adepu | J. VijayaRatna | Prakash V Diwan

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 01;
Start page: 22;
Date: 2012;
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Keywords: Domperidone | Glyceryl monostearate | DSC | PXRD | TEM | Entrapment efficiency

ABSTRACT
Domperidone (DOM) is a dopamine- receptor (D2) antagonist, widely used in the treatment of motion-sickness. The pharmacokinetic parameters of DOM make it a suitable candidate for development of Solid Lipid Nanoparticles (SLN). The purpose of the present investigation was to prepare and evaluate Domperidone loaded solid lipid nanoparticles (DOM-SLN). DOM loaded SLN were prepared by hot homogenization followed by ultrasonication technique. DOM- SLN were characterized for particle size, polydispersity index (PDI), zeta potential and entrapment efficiency and invitro drug release behaviour were investigated. P-XRD and DSC analysis were performed to characterize the state of drug and lipid modification. Shape and surface morphology were determined by transmission electron microscopy (TEM). SLN formulations were subjected to stability study over a period of 30 days. The mean particle size, PDI, Zeta potential and entrapment efficiency of optimised SLN were found to be 56 nm, 0.154, 34 mV, 98.5 %. P-XRD and DSC studies revealed that DOM was in an amorphous state. Shape and surface morphology was determined by TEM revealed fairly spherical shape of nanoparticles. Invitro release studies demonstrated that the SLN formulation possessed a controlled release over a period of 48 hrs. SLN formulations were subjected to stability over a period of 30 days. Fairly spherical shaped, stable and controlled release DOM-SLN could be prepared by hot homogenization followed by ultrasonication technique.

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