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6. Reproductive toxicity of Capparis aphylla (Roth.) in male albino rats

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Author(s): P. Revathi | B. Vani | I. Sarathchandiran | B. Kadalmani | K. Prakash Shyam | K. Palnivel

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 03;
Start page: 102;
Date: 2010;
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Keywords: Capparis aphylla | Male contraception | Infertility | Testis | Sperm | Medicinal plants.

ABSTRACT
The present study reflects the effect of ethanolic extract of Capparis aphylla (Roth.) on male reproduction and fertility in adult albino rat. The result revealed that the administration of whole plant ethanolic extract of C. aphylla manifested an antifertility effect on male reproductive system. The complete loss of fertility is attributed to decline in epididymal sperm counts and motility as well as origin of bi- and multinucleate giant cells in the ad luminal compartment of the testis was observed. The administration of ethanolic extract at varied doses led to alteration in both the histoarchitecture of testis, mainly caput epididymis and erratic spermatogenesis have been documented. The data revealed that functional sterility could be induced in male rats by whole plant ethanolic extract treatment, which promises to be a potential male contraceptive.

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