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7. Interaction of diclofenac sodium and atorvastatin in rodent model of acute inflammation

Author(s): S.A.Tiwari | B.R.Daswani | S.S.Dabhade | M.S.Khalse | B.B.Ghongane | P.S.Borle

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 03;
Start page: 167;
Date: 2012;
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Keywords: Atorvastatin | Drug interactions | Diclofenac | Anti-inflammatory activitiy

The objective of the present study was to investigate the possibility of any interaction between diclofenac and atorvastatin, with respect to anti-inflammatory effect, during combination therapy. 128 healthy albino rats divided in sixteen groups (n= 8) were used. These groups received a single dose of the following: diclofenac of 7.5, 15 or 30mg/kg, atorvastatin 2, 5 or 10mg/kg either alone or in combination with each of the doses of diclofenac orally as a suspension. These animals were subjected to acute inflammation by sub-plantar carrageenan injection and were evaluated for paw edema at 0, 3 and 6h. Atorvastatin (10mg/kg) in a single dose also showed significant anti-inflammatory (p< 0.005). As documented, this effect was noted with diclofenac (15, 30mg/kg). Addition of atorvastatin (2 or 5mg/kg) to diclofenac (7.5mg/kg) significantly increased its anti-inflammatory effect as compared to diclofenac 7.5mg/kg alone (p< 0.005) and that was comparable to that of diclofenac (15mg/kg). However, addition of atorvastatin 10mg/kg to diclofenac 15 or 30mg/kg did not further increase the anti-inflammatory effect. Combination of atorvastatin (2 or 5mg/kg) with diclofenac (7.5mg/kg) produced synergistic anti-inflammatory effect but this was not so with atorvastatin 10mg/kg since this dose itself produced a ceiling anti-inflammatory effect. However, studies in chronic models of inflammation are needed to confirm safety.
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