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7. Protective role of ethanolic extract of Sorghum bicolor leaf sheath against cadmium-induced oxidative stress in rats

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Author(s): E.T. Olayinka | A. Ore | O.O. Akinnawo

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 02;
Issue: 04;
Start page: 254;
Date: 2011;
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Keywords: Antioxidants | Cadmium | oxidative stress | hepatic toxicity | Sorghum bicolor

ABSTRACT
We investigated the protective effects of ethanolic extract of Sorghum bicolor leaf sheath (EESBLS) against Cadmium (Cd) – induced oxidative stress in rats. 35 rats (Rattus norvegicus) weighing 180±20 g, were randomized into seven groups of five animals each. Group I (control) received physiological saline, group II received 8mg/kg body weight (b.w.) of Cd, group III, 8mg/kg b.w. Cd and EESBLS (100mg/kg b.w.); group IV, 8mg/kg b.w. Cd and EESBLS (200mg/kg b.w.); group V, 8mg/kg b.w. Cd and EESBLS (400mg/kg b.w.), group VI, 8mg/kg b.w. Cd and EESBLS (800mg/kg b.w.) and group VII received EESBLS alone (800mg/kg b.w.). All treatments lasted for 7 days. Results show that Cd – induced toxicity was characterized by a significant increase (p
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