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8. Involvement of catecholamines in congestive heart failure, linked to lack of vitamin D and increased epidermal growth factor-receptor (EGF-R) production

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Author(s): Nadia M Hamdy | Lamiaa El-Wakeel

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 04;
Start page: 161;
Date: 2010;
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Keywords: CHF | 25-hydroxy vitamin D | fibrinogen | depression | catecholamines | EGF-R

ABSTRACT
In order to evaluate the role of sympathoadrenomedullary system in the causative mechanism of the anginal attack, the hemodynamic changes in heart failure were observed in 50 patients with congestive heart failure (CHF), compared to 20 normal subjects, and 20 patients with essential hypertension (HTN), all of whom had similar lifestyles; the overall age range was 18-60 years. Hence, we compared vitamin D, parathyroid hormone (PTH), calcium, lipids, the acute phase reactant highsensitivity C-reactive protein (hsCRP), fibrinogen, serotonin, norepinepherine (NE), and human epidermal growth factor receptor (EGF-R) between these groups. This study confirms a strong association between catecholamines as well as EGF-R levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. This study indicates that increased levels of lipids, fibrinogen, PTH, proinflammatory marker(s), catecholamines, and EGF-R, as well as low vitamin D, contribute to the complex process of atherosclerosis in hypertensive patients that leads eventually to CHF.
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