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8. Spectrophotometric method for simultaneous determination of atenolol and atorvastatin in tablet dosage forms

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Author(s): S. Dey | S. Sarkar | J. Malakar | A. Ghosh | A. Gangopadhyay | B. Mazumder

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 01;
Start page: 40;
Date: 2012;
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Keywords: Atenolol | Atorvastatin | Simultaneous estimation method | Method validation

ABSTRACT
A UV spectrophotometric method was developed for simultaneous estimation of atenolol and atorvastatin in tablet dosage form. The method is based upon determination of atenolol and atorvastatin at their respective λmax 225.0 nm and 241.0 nm, respectively. The linearity of atenolol and atorvastatin is established in the range of 5-30 µg/mL and 2-12 µg/mL, respectively. Results of analysis were validated statistically and by recovery studies. The limit of detection (LOD) and the limit of quantification (LOQ) for atenolol and atorvastatin were found to be 0.1765 and 0.5823 µg/mL, 0.5823 and 0.2522 µg/mL, respectively. The recovery study confirmed accuracy of proposed method and low values of relative standard deviation confirmed precision of method. The results of the study showed that the proposed method is simple, rapid, precise and accurate, which can be applied for the routine determination of atenolol and atorvastatin in tablet dosage forms.

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