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8. A study of serum levels of aluminium and select heavy metals in female rats fed phosphide-powder residue contaminated cowpea

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Author(s): A.A.Iyanda

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 03;
Start page: 172;
Date: 2012;
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Keywords: Heavy metal | Cowpea | Phosphide | Serum

ABSTRACT
The toxic mechanism of phosphide has always being linked to inhibition of the enzyme, cytochrome oxidase even when it is in aluminum salt (form). Aluminum when it is ingested in appreciable amount is toxic to a number of organs. Contamination of cowpea, after fumigation, with the unspent phosphide powder residue can result not only in exposure to phosphide but of Al. The aim of this study is to determine the serum levels of heavy metals (Al, Si, Cd, As, Ni, Pb) in rats exposed to cowpea contaminated phosphide residue. The experimental groups were three, with each group consisting of six rats each. While the control was given untreated cowpea, another group was fed treated but uncontaminated cowpea. The third group received phosphide residue contaminated cowpea. Of all the estimated metals, only Al was found to be significantly increased (p

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