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9. Screening of bark of Cinnamomum tamala (Lauraceae) by using α-amylase inhibition assay for anti-diabetic activity

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Author(s): R. Kumanan | S. Manimaran | Khan Saleemulla, | S.P. Dhanabal | M.J. Nanjan

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 01;
Issue: 02;
Start page: 69;
Date: 2010;
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Keywords: Cinnamomum tamala | Antidiabetic activity | α-Amylase | % inhibition | IC50

ABSTRACT
Diabetes is one of the major complications, the world faces today. Many reports suggest that Cinnamomum tamala (Lauraceae) has potent antidiabetic activity. The plant was selected based on their Ethno-pharmacological uses in traditional medicine. The present study focused on methanol and successive water extract of bark of Cinnamomum tamala was screened by using α-amylase inhibition assay for antidiabetic activity. The percentage inhibition values of methanol and successive water extract of bark of the Cinnamomum tamala were found 97.49% and 93.78% respectively. Similarly, IC50 values of methanol and successive water extract of the Cinnamomum tamala were found 1.80 and 5.53. The methanol extract of Cinnamomum tamala showed high potent activity than successive water extracts.

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