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Abnormal expression of dopamine and serotonin transporters associated with the pathophysiologic mechanism of Tourette syndrome

Author(s): Jijun Li | Zaiwang Li | Anyuan Li | Shuzhen Wang | Fanghua Qi | Lin Zhao | Hong Lv

Journal: Neurology India
ISSN 0028-3886

Volume: 58;
Issue: 4;
Start page: 523;
Date: 2010;
Original page

Keywords: DAT | Pathophysiology | SERT | Tourette syndrome

Background : Tourette syndrome (TS) is a neurobehavioral and neuropsychiatric disorder and its pathophysiology is not well understood. However, recent studies provide evidence implicating metabolic abnormalities of dopamine (DA) and serotonin (5-HT) of the basal ganglia both in TS patients and TS animal models. It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively. Objective : To evaluate whether expression of DAT and SERT in the striatum could lead to pathophysiological change in TS rat model. Materials and Methods : Twenty-four Wistar male rats were randomly allocated to: TS model group (n=12) and control group (n=12). The stereotypy counts were recorded during the 2-week period of inducing TS rat models. The levels of DA and 5-HT in striatum homogenate were measured by ELISA. The protein and mRNA expression of DAT and SERT in the striatum were tested respectively by Immunofluorescence, Western blot and quantitative real-time PCR. Results : ANOVA analysis indicated that the stereotypy scores were much higher in the TS model group than in the control group at different time points (P

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