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Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

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Author(s): Reinscheid Uwe

Journal: Nanoscale Research Letters
ISSN 1931-7573

Volume: 4;
Issue: 8;
Start page: 854;
Date: 2009;
Original page

Keywords: Gold nanoparticle | Magnetic field | Relaxation | Hydrolysis | Pro-drug

ABSTRACT
Abstract The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.
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