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Acetic acid ulcer model - state of the art in 2010

Author(s): Susumu Okabe | Kikuko Amagase | Koji Takeuchi

Journal: Polish Gastroenterology
ISSN 1232-9886

Volume: 17;
Issue: 3;
Start page: 165;
Date: 2010;
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Keywords: experimental chronic ulcer | malignant tumor | acetic acid ulcer therapy | EMR | ESD

Two types of a chronic ulcer model, named acetic acid ulcers, have been developed in experimental animals to examine the healing process of gastro-duodenum ulcers, screen ulcer-healing drugs, and evaluate the adverse effects of various anti-inflammatory drugs and/or Helicobacter pylori (H. pylori) infection on the gastrointestinal mucosa. The model demonstrates ease and reliability for producing round, deep ulcers in the stomach and duodenum in mice, rats, Mongolian gerbils, guinea pigs, cats, dogs, miniature pigs, and monkeys. One of the characteristic features of acetic acid ulcers in rats is the spontaneous relapse of healed ulcers >100 days after ulceration, an endoscopical examination confirmed the phenomenon. Indomethacin significantly delays the healing of acetic acid ulcers, probably by reducing endogenous prostaglandins and inhibiting angiogenesis in ulcerated tissue. H. pylori significantly delays healing of acetic acid ulcers and causes relapse of healed ulcers at a high incidence in Mongolian gerbils. Antisecretory drugs (e.g. omeprazole, lansoprazole) and mucosal defensive drugs (e.g. sucralfate, irsogladine maleate, rebamipide) are known to enhance healing of acetic acid ulcers. In addition, we discussed the potential usefulness of acetic acid ulcer models for early gastric tumor therapy by changing a malignant tumor to a benign ulcer by applying acetic acid under the tumor tissue or topically to the luminal surface of tumor tissue using an endoscope.
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