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Acquired Factor VII deficiency associated with pneumonia

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Author(s): Osman Yokuş | Özlem Şahin Balçık | Murat Albayrak

Journal: Journal of Clinical and Experimental Investigations
ISSN 1309-8578

Volume: 2;
Issue: 4;
Start page: 460;
Date: 2011;
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Keywords: Factor VII | deficiency | pneumonia

ABSTRACT
Factor VII (FVII) deficiency is a rare autosomal recessivecongenital coagulopathy associated withclinical bleeding and isolated prolongation of theprothrombin time (PT). Factor VII deficiency maypresent with hemorrhages of central nervous (CNS)and gastrointestinal (GIS) systems during infantileperiod or may be asymptomatic until adulthood.1However, acquired factor VII deficiency is extremelyrare.2,3,4,5 Although there are numerous reports regardingthe use of rFVIIa concentrate in patientswith hemorrhage owing to congenital FVII deficiency,little is known about secondary FVII deficiencyand its management. Here, we present the firstreport of an acquired FVII deficiency developed inan elderly woman during the course of communityacquiredpneumonia and discuss management approachesfor this very rare entity
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