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Activities of antioxidant enzymes in erythrocytes and tumor tissue in colorectal cancer patients Aktywnoœæ enzymów antyoksydacyjnych w erytrocytach i tkance guza u pacjentów z rakiem jelita grubego

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Author(s): Dorota Diakowska | Miros³aw Nienartowicz | Krzysztof Grabowski

Journal: Polish Gastroenterology
ISSN 1232-9886

Volume: 20;
Issue: 1;
Start page: 10;
Date: 2013;
Original page

ABSTRACT
Introduction: The role of antioxidant enzymes in colorectal cancer development is controversial. Aim of the study was to evaluate the activity of antioxidant enzymes in tumor tissues and accompanying normal tissues, and in erythrocytes in patients with colorectal cancer (CRC) stratified by the stage of disease and tumor location. Material and methods: Activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were measured in erythrocytes of healthy control (n=36) and in erythrocytes, tumor tissue and appropriate normal tissue of patients with surgically treated colorectal cancer (n=75). Results: Averages of CAT and GPx activities were significantly higher in tumors in comparison to normal mucosa (p=0.001 and p=0.038, respectively). CAT activity was significantly higher in the progression of cancer stage (p=0.001) and in cases with distant involvement compared to cases without distant involvement (p=0.004). SOD activity in the tumor located in sigma section was higher than in the tumor located in the proximal colon section (p=0.029). In erythrocytes, CAT activity was significantly higher in the colorectal cancer patients than the one obtained from the control group (p

Tango Jona
Tangokurs Rapperswil-Jona

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