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ACTIVITY OF LEAF EXTRACTS OF COIX LACHRYMA LINN. AND ASPARAGUS COCHINCHINENSISLINN. AS BREAST ANTICANCER DRUGS

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Author(s): RESMI MUSTARICHIE | ZALINAR UDIN | JUTTI LEVITA | IDA MUSFIROH | IKAL ZULFRICAR

Journal: Medical and Health Science Journal
ISSN 1804-1884

Volume: 9;
Issue: 5;
Start page: 47;
Date: 2011;
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Keywords: Ethanol extract | breast anticancer | Coix lachryma Linn | Asparagus cochinchinensis Linn | IC50 | Sulforhodamin B | MCF-7

ABSTRACT
In the current economic crisis, the use of plant medicine forcancer prevention should be investigated. Coix lachryma Linn and Asparagus cochinchinensis Linn are among eleven of species of medicinal plants that are noted as plant medicine for cancer in Indonesia, although their mechanism of action are still unknown. The eleven plants were screened using in vitro methods, Sulforhodamin B against breast cancer cells (MCF"7) and skin (KB). The research included a maceration process using ethanol as solvent and an anti"cancer testing process in vitro using Sulforhodamin B indicated by the value of percentage viability. Extracts were classed as being 'active anticancer' if they showed IC50 values below 100 ppm.. Coix lachryma Linn. and Asparagus cochinchinensis Linn. show breast and skin anticancer activity withIC50 values 6.51 ppm and 11.3 ppm of MCF"7 cells. The ethanol plant extracts were further extracted using various solvents with increasing polarity: n"hexane, methylene chloride, and ethyl acetate. The methylene chloride extract of Coix lachryma Linn. had IC50 = 2.75 ppm against MCF"7 cells. Against KB cells, methylene chloride extracts of Coix lachryma Linn. gave IC50 = 5.16 ppm. For Asparagus cochinchinensis Linn., an ethyl acetate extract had IC50 = 3.70 ppm against KB cancer cells and IC50 = 9.80 ppm against MCF"7 cancer cells. These data indicated that both plants can be used as anticancer drugs on breast and skin cancers.
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