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Acute toxicity study of alkaloids of Datura stramonium seeds in rat

Author(s): Bouzidi Abdelouahab; | Mahdeb Nadia | Kara Nabila

Journal: Research Opinions in Animal & Veterinary Sciences
ISSN 2221-1896

Volume: 1;
Issue: 8;
Start page: 482;
Date: 2011;
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Keywords: Datura stramonium | Rat | Liver | Alkaloids | Toxicity

The effects of acute administration of total alkaloids of Datura Stramonium seeds were studied in male and female Albino-Wister rats. After acute i.p administration of dose 100 mg/kg (1/4 DL50) of total alkaloids of Datura stramonium, there were no remarkable changes in general appearance and no deaths occurred in any experimental group in both sexes. The weight of treated animals has seen a normal evolution in comparison with that of control animals. Twenty four hours after the treatment, a significant reduction in the relative weight of liver was observed in treated rats. The RBC, HCT, HGB and WBC were significantly higher in the treated male rats than the control group. However, the treated female rats showed a significant decrease in RBC, HCT and HGB. There were no statistical differences in GOT, GPT and ALP between male rats at different intervals. However, an increase of transaminases was observed in female rats treated after the 1st day. The results showed that the acute toxicity of Datura stramonium had no deleterious effect on these parameters in male and female rats.
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