Academic Journals Database
Disseminating quality controlled scientific knowledge

ADDME – Avoiding Drug Development Mistakes Early: central nervous system drug discovery perspective

Author(s): Tsaioun Katya | Bottlaender Michel | Mabondzo Aloise

Journal: BMC Neurology
ISSN 1471-2377

Volume: 9;
Issue: Suppl 1;
Start page: S1;
Date: 2009;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Abstract The advent of early absorption, distribution, metabolism, excretion, and toxicity (ADMET) screening has increased the attrition rate of weak drug candidates early in the drug-discovery process, and decreased the proportion of compounds failing in clinical trials for ADMET reasons. This paper reviews the history of ADMET screening and its place in pharmaceutical development, and central nervous system drug discovery in particular. Assays that have been developed in response to specific needs and improvements in technology that result in higher throughput and greater accuracy of prediction of human mechanisms of absorption and toxicity are discussed. The paper concludes with the authors' forecast of new models that will better predict human efficacy and toxicity.

Tango Jona
Tangokurs Rapperswil-Jona

     Affiliate Program