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Adult-onset Still's Disease in the Etiology of Fever of Unknown Origin and Review of the Literature

Author(s): Mehmet Uluğ | Nuray Can Uluğ

Journal: Türkiye Fiziksel Tıp ve Rehabilitasyon Dergisi
ISSN 1302-0234

Volume: 56;
Issue: 2;
Start page: 97;
Date: 2010;
Original page

Keywords: Fever of unknown origin | adult-onset still’s disease | ferritin | treatment

Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis. Since a high fever is often the only manifestation, AOSD is regarded as an important cause of fever of unknown origin (FUO). The most important serological markers are hyperferritinemia, leukocytosis, negative antinuclear antibodies and rheumatoid factor. Nonsteroidal anti-inflammatory drugs, corticosteroids and immuno-modulating drugs are used for its treatment. In this study, we present an AOSD case, which was evaluated at the beginning as a FUO, and a review of the related data in the literature. Turk J Phys Med Rehab 2010;56:97-99.
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