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Advances in Oligoprotection

Author(s): Hong Liao | Dixit Sanjaya Mani

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 02;
Issue: 02;
Start page: 93;
Date: 2011;
Original page

Keywords: Oligodendrocytes | neurovascular unit | oxidative stress | excitotoxicity; demyelinating diseases | stroke | spinal cord injury | neuropharmacology

Oligodendrocytes, the myelinating glial cells of the nervous system, in various disease states display great vulnerability to excitotoxic damage, oxidative stress, and inflammatory cytokines. Besides demyelinating diseases where oligoden-drocyte injury is primarily implicated, damage to them also occurs secondarily in various neuropathies. Oligoprotec-tion should, therefore, be looked into something not just as a means for protecting oligodendrocytes alone but also as a common target of protecting neurons and the neurogliovascular unit as a whole. In this review, we provide a descrip-tion on oligodendrocytes, the reasons for their vulnerability, the evolving new concepts of protecting neurovascular unit and recently neurogliovascular unit; the various diseases where oligodendrocyte injury is implicated with a brief idea on different injury mechanisms of oligodendrocytes. Finally, we present the summary of the drugs that have shown promising results in protecting oligodendrocytes or in protecting white matter as a whole in different in-vivo and in-vitro models.
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