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AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy

Author(s): V. Nadeau | P. Hildgen

Journal: Molecules
ISSN 1420-3049

Volume: 10;
Issue: 1;
Start page: 105;
Date: 2005;
Original page

Keywords: AFM | PLA | Genetic Therapy | Vector | Salen | Schiff base.

The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
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