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Age-related changes in the content of insulin: Like growth factor-l in rat brain

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Author(s): Ćulić Milka | Grbić Gordana | Martać Ljiljana | Todorović Vera N. | Drndarević Neda Č. | Nikolić-Judith Anna | Kalauzi Aleksandar | Spasić Slađana Z.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 52;
Issue: 5-6;
Start page: 299;
Date: 2002;
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Keywords: IGF-I | brain | cerebellar cortex | ageing | rat

ABSTRACT
Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions.
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