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Alcoholic Cardiomyopathy: Clinical and Molecular Findings

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Author(s): M Correale | I Laonigro | F Altomare | MDi Biase

Journal: Iranian Cardiovascular Research Journal
ISSN 1735-885X

Volume: 2;
Issue: 1;
Start page: 1;
Date: 2008;
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Keywords: Alcoholic Cardiomyopathy | Heart Failure | Congestive Heart Failure

ABSTRACT
It has been known for some decades that chronic alcoholism can lead to dilated cardiomyopathy. Although excessivedrinking is known to result in alcoholic cardiomyopathy and light-to-moderate drinking may confer somecardiovascular benefits, recent studies suggest that it is not only the quantity, but also drinking patterns and genetic factors, that may influence the relation between alcohol consumption and cardiovascular disease. Alcoholicpatients consuming > 90g of alcohol a day for > 5 years are at risk for the development of asymptomatic alcoholiccardiomyopathy. Those who continue to drink may become symptomatic and develop signs and symptoms ofheart failure. We summarize the experimental and clinical evidence regarding the role of alcohol in pathophysiologyof alcoholic cardiomyopathy.
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