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Algorithm of Insulin Human P01308 – Amino acids Thr, Asn, and Pro

Author(s): Lutvo Kuric

Journal: Biomirror
ISSN 0976-9080

Volume: 2;
Issue: September;
Start page: 1;
Date: 2011;
Original page

Keywords: Human insulin | Algorithm | Insulin model | Insulin code | Determinant of insulin.

The modern science mainly treats the biochemical basis of sequencingin bio-macromolecules and processes in medicine and biochemistry.One can ask whether the language of biochemistry is the adequatescientific language to explain the phenomenon in that science. Is there maybe some other language, out of biochemistry, that determines how the biochemical processes will function and what the structure andorganization of life systems will be? The research results provide some answers to these questions. They reveal to us that the process ofsequencing in bio-macromolecules is conditioned and determined notonly through biochemical, but also through cybernetic and informationprinciples. Many studies have indicated that analysis of protein sequence codes and various sequence-based prediction approaches, such as predicting drug-target interaction networks (He et al., 2010),predicting functions of proteins (Hu et al., 2011; Kannan et al., 2008), analysis and prediction of the metabolic stability of proteins (Huang etal., 2010), predicting the network of substrate-enzyme-product triads (Chen et al., 2010), membrane protein type prediction (Cai and Chou, 2006; Cai et al., 2003; Cai et al., 2004), protein structural class prediction (Cai et al., 2006; Ding et al., 2007), protein secondary structure prediction (Chen et al., 2009; Ding et al., 2009b), enzyme family class prediction (Cai et al., 2005; Ding et al., 2009a; Wang etal., 2010), identifying cyclin proteins (Mohabatkar, 2010), protein subcellular location prediction (Chou and Shen, 2010a; Chou and Shen, 2010b; Kandaswamy et al., 2010; Liu et al., 2010), among many others as summarized in a recent review (Chou, 2011), can timely provide very useful information and insights for both basic research and drug design and hence are widely welcome by science community. The present study is attempted to develop a novel sequence-based method for studying insulin in hopes that it may become a useful tool in the relevant areas.

Tango Jona
Tangokurs Rapperswil-Jona

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