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Allele Frequency of CYP2C19 Gene Polymorphisms in a Healthy Iranian Population

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Author(s): Negin Zand | Nader Tajik | Mahmood Hoormand | Alireza Salek Moghaddam | Iraj Milanian

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 4;
Issue: 2;
Start page: 124;
Date: 2005;
Original page

Keywords: CYP2C19 | Iranian population | PCR-RFLP | Pharmacogenetics | Polymorphism

ABSTRACT
Cytochrome P450 2C19 (CYP2C19) plays an important role in the metabolism and elimination of a wide range of medications. The polymorphisms of this enzyme give rise to substantial inter-individual and inter-ethnic variability in drug excretion rates and final serum concentrations. For this reason, therapeutic re-sponses and adverse drug reactions may vary from one person to another. In this study we determined genotypes of CYP2C19 in Iranian population to compare allele frequencies with previous findings in other ethnic groups. CYP2C19 (*1/*2/*3) allelic variants were determined in 200 unrelated healthy Iranian vol-unteers by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. Six subjects (3%) were homozygous for CYP2C19*2, while 44 individuals (22%) were heterozygous. In the remainder (75%) no CYP2C19*2 was found. In addition, no CYP2C19*3 was detected in the population studied. Based on our data, there was no difference between frequency of CYP2C19 allelic variants in our study and other evaluated Caucasians (p > 0.05).

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