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Alteration in Liver Enzymes in Aluminum Phosphide Poisoning, A Retrospective Study

Author(s): Morteza Rahbar Taramsari | Alireza Badsar | Afshin Shafaghi | Maryam Namakchian Namakin | Hannan Ebrahimi | Morteza Fallah Karkan

Journal: Iranian Journal of Toxicology
ISSN 2008-2967

Volume: 7;
Issue: 21;
Start page: 854;
Date: 2013;
Original page

Keywords: Aluminum Phosphide | Poisoning | Transaminases.

Background: Aluminum phosphide (ALP) or rice tablet is a common agent used aspesticides. It is cheap, widely available and highly toxic and responsible for many casesof poisoning in the agricultural communities. There is limited evidence about change ofliver enzymes in patients with ALP poisoning in this region. Therefore, we decided toevaluate alteration of liver enzymes in ALP poisoning in Rasht.Methods: In this retrospective cross-sectional study, all documents of patients withALP poisoning admitted to Razi hospital of Rasht in 2008-2009 were assessed.Inclusion criteria were diagnostic clinical manifestation such as hypotension ormetabolic acidosis, history of exposure to ALP during the past 24 hours and progressivesigns and symptoms despite treatment (administration of sodium bicarbonate andvasopressor). Patients with past history of hepatic disease were excluded. Collecteddata were analyzed with SPSS software.Results: Of 104 patients with ALP poisoning, 66 patients (63.5%) were men. Themean age was 33.8±14.69 years, and the mean time of hospitalization was 14.94±18.28hours. Ninety-five patients (91.3%) needed ventilation and 93 patients (89.4%) died.Statistical analysis demonstrated that elevated liver enzymes were not significantlyrelated with gender, age, time of admission, time of hospitalization, the need forventilation and mortality.Conclusion: It seems that liver enzymes changes is not seen widely in ALP poisoningand had lower importance than other complications. Because of limited studies in liverenzyme alterations in these patients, it is suggested that more studies with largeesample size is performed to investigate the ALP liver side effects.
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