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Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals

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Author(s): Prakash Chandra | Sukhdeep S. Basra | Tai C. Chen | Vin Tangpricha

Journal: International Journal of Endocrinology
ISSN 1687-8337

Volume: 2010;
Date: 2010;
Original page

ABSTRACT
Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50–125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52±11 to 40±7 mg/dL) (P
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