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Alterations of serum biomarkers associated with lung ventilation function impairment in coal Workers: A cross-sectional study

Author(s): Zou Jimin | du Prel Carroll Xianming | Liang Xianhong | Wang Dongmei | Li Chao | Yuan Baojun | Leeper-Woodford Sandra

Journal: Environmental Health
ISSN 1476-069X

Volume: 10;
Issue: 1;
Start page: 83;
Date: 2011;
Original page

Keywords: Coal workers' pneumoconiosis | pulmonary function | serum biomarkers | interleukins

Abstract Background Previous studies have demonstrated that alterations in certain circulating biomarkers may be correlated with Coal workers' pneumoconiosis (CWP). This study investigated the relationship between changes of serum biomarkers and pulmonary function during the development of CWP. Methods Lung function parameters and specific serum indices were measured in 69 non-smoking coal workers, including 34 miners with CWP, 24 asymptomatic miners and 11 miners with minimal symptoms. The associations between changes in pulmonary function and serum indices were tested with Pearson's correlation coefficients. Multivariable analysis was used to estimate the predictive power of potential determinant variables for lung function. Results Compared to healthy miners, lung function (FVC, FEV1, FEF50, FEF75, FEF25-75 % of predicted values) was decreased in miners with CWP (p < 0.05). Increased serum matrix metalloproteinase-9 (MMP-9) was associated with decreased FVC% of predicted values in the asymptomatic miners (r = -0.503, p = 0.014). Conclusions In coal mine workers, alterations of lung function parameters are associated with the development of CWP and with changes in circulating MMP-9, TIMP-9, IL-13 and IL-18R. These serum biomarkers may likely reflect the pathogenesis and progression of CWP in coal workers, and may provide for the importance of serum indicators in the early diagnosis of lung function injury in coal miners.

Tango Jona
Tangokurs Rapperswil-Jona

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