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Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension

Author(s): Nandeesha H | Sathiyapriya V | Bobby Zachariah | Pavithran P | Agrawal Aparna | Selvaraj N

Journal: Indian Journal of Medical Sciences
ISSN 0019-5359

Volume: 61;
Issue: 6;
Start page: 326;
Date: 2007;
Original page

Keywords: Antioxidants | essential hypertension | oxidative stress

Background : Although a wide number of experimental evidences are available regarding oxidant-antioxidant disturbance in hypertension, clinical data supporting it is lacking in men in early stages of hypertension. Aims: The objective of the study was to evaluate oxidative status and antioxidant activities in males with stage I essential hypertension. Materials and Methods : Thirty hypertensives and 21 normotensives were included in the study. Protein carbonyl, reduced glutathione, glutathione peroxidase, catalase and fasting glucose were assessed in both the groups. Statistical Analysis : Results were analyzed by student′s ′t′ test and linear regression analysis test. Results : Plasma protein carbonyl and glutathione peroxidase were significantly increased, and catalase and GSH were significantly reduced in the hypertensive group compared to normotensive subjects. There was a significant negative correlation between glutathione peroxidase and catalase in the test group. Conclusions : The data from the present study indicates an alteration in oxidant-antioxidant status in non-obese men in early stages of essential hypertension.
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