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Amlodipine advantages in arterial hypertension therapy

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Author(s): V.M. Tsareva | N.J. Hozjainova | M.S. Bezaltynnyh | T.V. Brook | N.A. Borohova | I.E. Koltunov | N.M. Ahmedzhanov

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 4;
Issue: 5;
Start page: 53;
Date: 2008;
Original page

Keywords: arterial hypertension | heart rate variability | cardiovascular remodeling | microcirculation.

ABSTRACT
Aim. To study effects of calcium channel blocker, amlodipine on indices of ambulatory blood pressure monitoring (ABPM), heart rate variability, corrected QT-interval and its dispersion, structural and functional heart indices, microcirculation in patients with arterial hypertension (HT).Material andmethods. 48 patients with HT of 1-2 stages were involved in the study. After 2 week wash-out period amlodipine (5-10 mg/day) therapy was started. ABPM, 24 hour electrocardiogram monitoring, echocardiography, laser Doppler flowmetry was performed initially and in 24 weeks of therapy.Results. Amlodipine therapy increased microcirculation efficacy, reduced repolarization nonhomogeneity, contributed to myocardial electrophysiological stability. Besides it improved structural and functional heart indices, decreased systolic and diastolic blood pressure (BP), reduced indices of BP load during a day.Conclusion. Amlodipine is effective antihypertensive medicine, having prominent cardio- and vasoprotective effects and good tolerability.
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