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Amlodipine in correction of high risk arterial hypertension: focus on mechanisms of inflammation

Author(s): A.A. Tarasov | S.I. Davydov | T.A. Bezborodova | M.A. Gordeeva | A.R. Babaeva

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 7;
Issue: 5;
Start page: #;
Date: 2011;
Original page

Keywords: amlodipine | arterial hypertension | ischemic heart disease | diabetes mellitus | inflammatory markers.

Aim. To study the effect of amlodipine on the main indicators of systemic inflammation and its safety in patients with arterial hypertension (HT) in combination with ischemic heart disease (IHD) or diabetes mellitus (DM) type 2.Material and methods. Patients with HT (2-3 degree) associated with IHD or DM type 2 were included into the study. Patients were randomized into main group (n=30) receiving amlodipine 5-10 mg daily in addition to standard therapy (ACE inhibitors, beta-blockers, aspirin, statins, hypoglycemic agents), or into control group (n=30) receiving only standard therapy. Efficacy and safety of the therapy was evaluated by clinical, instrumental and laboratory parameters. Dynamics of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and C-reactive proteine (CRP) levels were determined to evaluate the activity of systemic inflammation. Treatment duration was 6-8 weeks.Results. Blood pressure reduction by 17.1±5.8/11.4±4.0 mmHg (p
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