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Amyloid precursor protein regulates brain cholesterol metabolism

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Author(s): Radosveta Koldamova

Journal: Neurobiology of Lipids
ISSN 1683-5506

Volume: 6;
Start page: 3;
Date: 2007;
Original page

Keywords: Alzheimer's disease | amyloid precursor protein | APP | gamma secretase | lipoprotein receptor | HDL | cholesterol | AICD | Abca1 | LXR | Apolipoprotein E | Apo E

ABSTRACT
There is a scientific evidence, suggesting that amyloid precursor protein (APP) processing and Alzheimer's (AD) amyloid beta generation are regulated by cholesterol. Latest study by Liu et al. published in Neuron (56:66-78, 2007) shines a new light on the connection between cholesterol metabolism and APP processing. At this time the story is reversed - now it appears that APP proteolytic fragments are regulating cholesterol levels in brain and inside the cells.

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