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Amyotrophic lateral sclerosis associated with pregnancy.

Author(s): Tyagi A | Sweeney B | Connolly S

Journal: Neurology India
ISSN 0028-3886

Volume: 49;
Issue: 4;
Start page: 413;
Date: 2001;
Original page

Keywords: Adult | Amyotrophic Lateral Sclerosis | diagnosis | drug therapy | physiopathology | Electromyography | Female | Human | Magnetic Resonance Imaging | Neuroprotective Agents | therapeutic use | Pregnancy | Pregnancy Complications | diagnosis | drug therapy | physiopathology | Riluzole | therapeutic use

Amyotrophic lateral sclerosis (ALS) is the most common, progressive motor neurone disease but is rare in the obstetric population. Only 4 cases have been described in the English literature since 1975. We describe a 29 year old woman who presented with ataxia, lower limb weakness and dysarthria 4 weeks after the birth of her first child. The symptoms had onset during the pregnancy but had not been considered remarkable. There were clinical features of upper and lower motor neurone involvement without any sensory loss. MRI of brain and spine was normal. CSF analysis was negative. EMG studies confirmed the presence of widespread anterior horn cell dysfunction compatible with ALS. The patient was commenced on Riluzole and has progressed clinically, at 12 months post diagnosis.
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