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Anaerobic Glycolysis is the Main Pathway for Energy Generation in HL-60 Acute Promyelocytic Leukemia Cells

Author(s): Hakan Boyunaga | Hatice Keles | Levent Kenar | Ali Ural | Ferit Avcu

Journal: Journal of Clinical and Analytical Medicine
ISSN 1309-0720

Volume: 1;
Issue: 2;
Start page: 5;
Date: 2010;
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Keywords: Energy Metabolism | HL-60 Promyelocytic Leukemia Cell | Glycogen Degradation

Aim: In physiological conditions, normal cells use mainly the glycolytic aerobic pathway to provide energy. However, most cancer cells utilize anaerobic glycolytic way for energy generation. Aim of this study was to investigate the carbohydrate metabolic pathways of HL-60 acute promyelocytic leukemia cells for energy production. Material and Methods: Leukemia cells as well as normal leukocytes were incubated with radiolabelled glucose in aerobic and anaerobic conditions and glycogen consumptions and the ratios of radiolabelled glucose catabolized into CO2 or lactate, that is, the rates of aerobic or anaerobic glycolysis, were determined. Results: The glycogen consumption was significantly higher in aerobic leukemia cell culture than normal leukocyte culture (p

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