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ANALGESIC ACTIVITY OF PARTHENIUM CAMPHORA IN MICE MODELS OF ACUTE PAIN

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Author(s): Sravan Kumar Bussa

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 6;
Start page: 13;
Date: 2010;
Original page

Keywords: Analgesic activity triterpenoids | Tail flick assay | Tail formalin test | parthenium camphora | Writhing test.

ABSTRACT
Leaf extracts of parthenium camphora are used in Chilean folk medicine as analgesic and anti-inflammatory. The antinociceptive effect of dichloromethane (DCM), ethyl acetate (EA) and methanol (ME) leaf extracts was assessed by intraperitoneal, oral and topical administration in writhing, tail flick, and tail formalin tests in mice. The extracts showed a dose-dependent antinociceptive activity in all the assays under different administration routes. The ED50 values for the different tests for the DCM, EA, ME extract and reference drug (ibuprofen) were as follows. Writhing test in acetic acid (i.p. administration): 0.21, 0.37, 1.37 and 0.85 mg/kg, respectively; tail flick test (oral administration): 199, 189, 120 and 45.9 mg/kg. The EC50 values for tail flick test were (topical administration): 2.0, 0.35, 1.4 and 8.2% (w/v), respectively; and the topical analgesic effects were (formalin assay) 75.5, 77.5, 31.6 and 76.5%, respectively. Parthenium camphora extracts produce antinociception in chemical and thermal pain models through a mechanism partially linked to either lipooxygenase and/or cyclooxygenase via the arachidonic acid cascade and/or opioid receptors. Flavonoid glycosides and triterpenoids have been isolated from the plant and can be associated with the observed effect. Our results corroborate the analgesic effects of parthenium camphora, and justify its traditional use for treating pain.
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